Identification of Conserved B-Cell Epitope Candidates Associated with Neutralizing Activity of Bovine Coronavirus Spike Protein.

Yunxin Ren, Hua Yue, Cheng Tang, Xi Chen

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunxin RenKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0002-7505-990X

Hua YueKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.

Cheng TangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.

Xi ChenKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.

Funding

National Key Research and Development Program of China during the 14th Five-Year Plan 2023YFD180250402Southwest Minzu University Double World-Class Project XM2023014

6 · The paper itself

Abstract

Bovine coronavirus (BCoV) is a major cause of respiratory and enteric diseases in cattle, resulting in substantial economic losses to the global cattle industry. Next-generation epitope-focused vaccines require conserved neutralizing determinants to achieve broad protective efficacy across circulating variants. Here, we applied a reverse-vaccinology and immunoinformatics-guided strategy to identify conserved linear B-cell epitope candidates on the BCoV spike protein. Using ABCPred (16 aa; threshold score 0.51), 139 putative linear B-cell epitopes were predicted, and 10 candidates (B1-B10) were selected based on antigenicity, allergenicity/toxicity filters, and Shannon-entropy-based conservation (≥95%). Each candidate was displayed on

Indexed as

B-cell epitope candidatesbovine coronavirusferritin nanoparticleneutralizing antibodyspike protein

Identifiers

PMID42652003

DOI10.3390/ani16162598

PMCPMC13508896

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.