Evidence map›Paper›PMID 42652976›Full record

ArticleLife (Basel, Switzerland)2026

Combined Effects of Physiotherapy and Vitamin D Supplementation on Pain, Disability, and IL-6 Expression in Chronic Low Back Pain: A Randomized Controlled Trial.

Abdulaziz A Albalwi, Hamad S Al Amer, Rashid Mir, Shahul Hameed Pakkir Mohamed, Jamsheed Javid, Mohammad Muzaffar Mir, Waad Alamri, Yousef M Alshehre, Ahmad A Alharbi

Abstract read
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Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdulaziz A AlbalwiDepartment of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-2496-2226
Hamad S Al AmerDepartment of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-5859-7258
Rashid MirPrince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia.
Shahul Hameed Pakkir MohamedDepartment of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-5003-7501
Jamsheed JavidDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Mohammad Muzaffar MirDepartment of Clinical Biochemistry, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.ORCID 0000-0003-2068-3075
Waad AlamriPrince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia.
Yousef M AlshehreDepartment of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-2374-7716
Ahmad A AlharbiDepartment of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-3086-2640

Funding

University of Tabuk S-1443-0200
6 · The paper itself

Abstract

backgroundChronic low back pain (CLBP) is a leading cause of global disability, linked to elevated IL-6 and vitamin D deficiency or insufficiency. While interferential current (IFC) therapy and exercise therapy are established treatments, their combined effect with vitamin D supplementation on inflammatory biomarkers, pain, and functional disability remains underexplored.

objectiveThe aim of this study was to evaluate the combined effects of physiotherapy and vitamin D supplementation on pain, disability, IL-6 expression, and vitamin D levels in CLBP patients.

methodsThis two-arm, parallel-group, randomized controlled trial enrolled 60 CLBP patients, randomized into Group A (physiotherapy alone: IFC therapy and exercise therapy;

resultsBoth groups showed significant improvements in NPRS and ODI at six weeks (

conclusionsCombining physiotherapy with vitamin D supplementation improves outcomes in the management of CLBP. This approach effectively reduces pain, functional disability, inflammation, and vitamin D deficiency or insufficiency, offering a comprehensive, evidence-based treatment strategy.

Indexed as

electric stimulation therapyexercise therapyinterleukin-6low back painphysical therapy modalitiesvitamin D

Identifiers

PMID42652976
PMCPMC13514135

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.