Evidence map›Paper›PMID 42653038›Full record

ReviewLife (Basel, Switzerland)2026

The Kynurenine Pathway in Tuberculosis: Focus on Immunometabolic Regulation, Compartment-Specific Biology, and Therapeutic Potential.

Piotr Stasiak, Kacper Kraśnik, Maciej Biskupski, Aleksandra Tarka, Michał Flis, Ewa M Urbańska

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Piotr StasiakDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0009-0008-4377-9604
Kacper KraśnikDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0009-0009-3223-1026
Maciej BiskupskiDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0009-0000-4040-8068
Aleksandra TarkaDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0009-0004-2645-848X
Michał FlisDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0009-0005-6215-1298
Ewa M UrbańskaDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0000-0002-2704-528X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) remains a global health problem, and attention is focused on host immunometabolic pathways influencing antimicrobial immunity, tissue injury, and treatment response. This comprehensive review integrates evidence on the kynurenine pathway (KP) of tryptophan (TRP) metabolism in TB and evaluates its potential as a host-directed therapeutic target. Evidence from human cohorts, in vitro systems, animal models, and non-human primates indicates that

Indexed as

granulomahost-directed therapyIDO1immunometabolismkynurenine pathwaytryptophan metabolismtuberculosis

Identifiers

PMID42653038
PMCPMC13514684

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.