ArticleInternational journal of molecular sciences2026
Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans.
Anna K Scheurer-Böhme, Eileen Moritz, Stefan Weiss, Robin Bülow, Marie-Luise Kromrey, M Kamal Nasr, Uwe Völker, Henry Völzke, Stefan Engeli, Jens-Peter Kühn and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Anna K Scheurer-BöhmeDepartment of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C DAT), University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.
Eileen MoritzDepartment of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C DAT), University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.
Stefan WeissInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0002-3553-4315 Robin BülowDZHK (German Centre for Cardiovascular Research), Partner Site North, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0003-1884-5784 Marie-Luise KromreyInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0002-0420-7303 M Kamal NasrDZHK (German Centre for Cardiovascular Research), Partner Site North, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0009-0004-2816-7168 Uwe VölkerInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0002-5689-3448 Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.
Stefan EngeliDepartment of Clinical Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C DAT), University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.
Jens-Peter KühnInstitute and Policlinic for Diagnostic and Interventional Radiology, University Hospital, Carl Gustav Carus University, TU Dresden, 01304 Dresden, Saxony, Germany.
Alexander TeumerDZHK (German Centre for Cardiovascular Research), Partner Site North, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0002-8309-094X Mladen V TzvetkovDepartment of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C DAT), University Medicine Greifswald, 17475 Greifswald, Mecklenburg-Western Pomerania, Germany.ORCID 0000-0003-1670-5534 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Fatty liver is associated with increased all-cause mortality. Organic cation transporter 1 (OCT1) is a polyspecific hepatic uptake transporter. OCT1 mediates hepatic uptake of vitamin B1 (thiamine); thus, OCT1 deficiency may impair thiamine availability and consequently reduce glucose-derived energy. Consequently, OCT1-knockout mice exhibit significantly reduced liver fat. In 2% of Europeans and White Americans, common genetic variants markedly reduce OCT1 function. In this study, we used these naturally occurring variants to investigate the influences of reduced OCT1 function on liver fat in humans. We analyzed 2512 whole-body MRI datasets from the Study of Health in Pomerania (SHIP) and validated the findings using 31,594 datasets from the UK Biobank. In both cohorts, OCT1 deficiency was associated with lower fat content in the liver (
Indexed as
Fatty LiverLiverOctamer Transcription Factor-1Organic Cation Transporter 1AgedAnimalsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOctamer Transcription Factor-1Organic Cation Transporter 1hepatic steatosismetabolic dysfunction-associated steatotic liver diseasemetabolic phenotypemitochondrial respirationnon-alcoholic fatty liver diseaseOCT1organic cation transporterStudy of Health in PomeraniaUK Biobank
Identifiers
PMID42653422
PMCPMC13513528
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