Evidence map›Paper›PMID 42653455›Full record

ArticleInternational journal of molecular sciences2026

Effects of Iloprost on TRPM7-Mediated Apoptosis and Oxidative Stress in an Experimental Testicular Torsion-Detorsion Model.

Nalan Kaya Tektemur, Aysenur Bilgetay Unlu, Merve Kavak Balgetir, Ahmet Tektemur, Gonca Ozan Kocamuftuoglu, Ramazan Fazil Akkoc, Osman Fatih Yilmaz, Esra Aydemir, Tuncay Kuloglu

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nalan Kaya TektemurDepartment of Histology and Embryology, Faculty of Medicine, Firat University, Elaziğ 23119, Türkiye.ORCID 0000-0001-8880-4932
Aysenur Bilgetay UnluDepartment of Histology and Embryology, Faculty of Medicine, Firat University, Elaziğ 23119, Türkiye.
Merve Kavak BalgetirDepartment of Histology and Embryology, Elazig Fethi Sekin City Hospital, Elaziğ 23280, Türkiye.ORCID 0000-0001-9745-3660
Ahmet TektemurDepartment of Medical Biology, Faculty of Medicine, Firat University, Elaziğ 23119, Türkiye.ORCID 0000-0002-2476-0413
Gonca Ozan KocamuftuogluDepartment of Biochemistry, Faculty of Medicine, Burdur Mehmet Akif Ersoy University, Burdur 15030, Türkiye.ORCID 0000-0001-6874-3669
Ramazan Fazil AkkocDepartment of Anatomy, Faculty of Medicine, Kutahya Health Sciences University, Kütahya 43020, Türkiye.ORCID 0000-0002-0559-8932
Osman Fatih YilmazPathology Laboratory Techniques, Faculty of Medicine, Mus Alparslan University, Muş 49250, Türkiye.ORCID 0000-0002-4962-387X
Esra AydemirDepartment of Histology and Embryology, Faculty of Medicine, Firat University, Elaziğ 23119, Türkiye.
Tuncay KulogluDepartment of Histology and Embryology, Faculty of Medicine, Firat University, Elaziğ 23119, Türkiye.ORCID 0000-0001-9874-3838

Funding

Fırat University TF.26.55
6 · The paper itself

Abstract

Testicular torsion is a urological emergency that causes ischemia-reperfusion (I/R) injury and may result in irreversible germ cell loss and impaired fertility. Oxidative stress, inflammation, and apoptotic pathways play central roles in its pathogenesis. Transient Receptor Potential Melastatin-7 (TRPM7), a bifunctional ion channel/kinase, has recently been implicated in I/R-related cellular injury. Iloprost, a prostacyclin analogue with vasodilatory and antioxidant properties, may offer protective effects; however, its impact on TRPM7-mediated pathways in testicular I/R injury remains unclear. This study aimed to investigate the effects of iloprost on oxidative stress, apoptosis, and TRPM7 expression in an experimental testicular torsion-detorsion model. Thirty-five male Sprague Dawley rats were randomized into five groups: control, sham, iloprost, torsion-detorsion (T/D), and T/D + iloprost. After 60 min of torsion and subsequent detorsion, iloprost (2 µg/kg, intraperitoneal) was administered in the treatment group. Testicular tissues and serum samples were analyzed after 48 h. Histopathology (H&E), apoptosis (TUNEL assay), TRPM7 immunohistochemistry and mRNA expression (RT-qPCR), and serum total antioxidant status (TAS) and total oxidant status (TOS) were evaluated. Torsion-detorsion significantly increased TOS levels, apoptotic cell ratio (ACR), TRPM7 expression, and Bax mRNA expression, while reducing TAS levels (

Indexed as

ApoptosisIloprostOxidative StressProtein Serine-Threonine KinasesReperfusion InjurySpermatic Cord TorsionTRPM Cation ChannelsAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyTestisIloprostProtein Serine-Threonine KinasesTrpm7 protein, ratTRPM Cation Channelsgerm cell apoptosisiloprostischemia–reperfusion injuryoxidative stresstesticular torsionTRPM7

Identifiers

PMID42653455
PMCPMC13513499

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.