Evidence map›Paper›PMID 42653456›Full record

ArticleInternational journal of molecular sciences2026

Bcl-2-Dependent Persistence of Mononuclear Phagocytes Promotes Ocular Fibrosis.

Yong-Seok Song, Shoujian Wang, Soesiawati R Darjatmoko, Nader Sheibani, Christine M Sorenson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yong-Seok SongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Shoujian WangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Soesiawati R DarjatmokoDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.ORCID 0000-0003-2723-9217
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
Bcl-2, Subretinal Scar Formation and Neovascular AMDR21EY034646 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2023 to 2023
$428k
Carl Marshall and Mildred Almen Reeves Foundation AMD Research AwardEdward N. & Della L. Thome Memorial Foundation AMD Research AwardNCI NIH HHS P30 CA014520NEI NIH HHS EY034646NEI NIH HHS P30 EY016665NEI NIH HHS R21 EY034646Pat and Jay Smith AMD Innovation Fund AMD Research AwardResearch to Prevent Blindness Unrestricted award to the Department of Ophthalmology and Visual SciencesRetina Research Foundation Endoument Funds
6 · The paper itself

Abstract

Ocular diseases, such as neovascular age-related macular degeneration (nAMD) and proliferative vitreoretinopathy (PVR), have a fibrotic component that negatively impacts vision. Unfortunately, few treatments are available to mitigate fibrosis in the eye. The clearance of inflammatory cells proceeds, at least in part, through the intrinsic cell death pathway in which Bcl-2 family members play integral roles. Here, we assessed the influence of Bcl-2 expression in mononuclear phagocytes (MP) on the engagement and clearance of inflammatory cells, choroidal neovascularization (CNV), and subsequent subretinal fibrosis in a mouse laser-induced CNV model. Lack of Bcl-2 expression in MP (Bcl-2

Indexed as

Choroidal NeovascularizationPhagocytesProto-Oncogene Proteins c-bcl-2AnimalsDisease Models, AnimalFibrosisMacrophagesMiceMice, Inbred C57BLBcl2 protein, mouseProto-Oncogene Proteins c-bcl-2Bcl-2choroidal neovascularizationfibrosisinflammationmacrophagesneutrophilsproliferative vitreoretinopathy

Identifiers

PMID42653456
PMCPMC13513839

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.