Silk Fibroin Peptides Promote Extracellular Matrix Homeostasis in Photoaging via Modulation of the ITGB1/FAK-TGF-β/Smad Signaling Axis.

Siyuan He, Yongqiu Yan, Feifei Xiong, Wenwen Diao, Fuhuai Jia, Xiaodong Yan, Jing Wang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siyuan HeKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.

Yongqiu YanZhejiang Daldrem Biotechnology Co., Ltd., Ningbo 315153‌, China.

Feifei XiongZhejiang Daldrem Biotechnology Co., Ltd., Ningbo 315153‌, China.

Wenwen DiaoZhejiang Daldrem Biotechnology Co., Ltd., Ningbo 315153‌, China.

Fuhuai JiaZhejiang Daldrem Biotechnology Co., Ltd., Ningbo 315153‌, China.

Xiaodong YanKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-1990-8927

Jing WangKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive ultraviolet A (UVA) irradiation disrupts extracellular matrix (ECM) homeostasis in skin photoaging by impairing the balance between synthesis and degradation, yet whether silk fibroin peptide (SF), a small bioactive peptide from

Indexed as

Extracellular MatrixFibroinsIntegrin beta1PeptidesSkin AgingAnimalsBombyxFibroblastsFocal Adhesion Kinase 1HomeostasisHumansOxidative StressReactive Oxygen SpeciesSignal TransductionSmad ProteinsTransforming Growth Factor betaFibroinsFocal Adhesion Kinase 1Integrin beta1Itgb1 protein, humanPeptidesPTK2 protein, humanReactive Oxygen SpeciesSmad ProteinsTransforming Growth Factor betaextracellular matrix homeostasishuman dermal fibroblastsintegrin β1 (ITGB1)photoagingsilk fibroin peptide

Identifiers

PMID42653901

DOI10.3390/molecules31162820

PMCPMC13515133

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.