Screening of Dietary Flavonoids for Synergistic α-Glucosidase Inhibition with 1-Deoxynojirimycin and Elucidation of the Underlying Molecular Mechanism.

Lin Wang, Jun Liu, Yonghong Zhao, Zhongshan Xiao, Lei Zeng, Zhuming Liu, Wei Wang, Baogang Wang, Jinping Wang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin WangSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Jun LiuSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Yonghong ZhaoNanjing Institute for Food and Drug Control, Nanjing 211198, China.

Zhongshan XiaoDepartment of Pharmacy, Puyang Medical College, Puyang 475000, China.

Lei ZengSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Zhuming LiuSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Wei WangSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Baogang WangCollege of Food Science and Engineering, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Jinping WangSchool of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Funding

Science and Technology Tackling Key Project of Henan Province 252102311280

6 · The paper itself

Abstract

1-Deoxynojirimycin (DNJ), a well-characterized α-glucosidase inhibitor, remains an important target for dose-reduction and formulation strategies. In the present study, we evaluated the individual and combined α-glucosidase inhibitory activities of nine dietary flavonoids with DNJ, quantified synergistic effects using the combination index (CI) method, and elucidated the molecular mechanism through integrated enzyme kinetics, multi-spectroscopic techniques and molecular docking. (+)-Catechin exhibited the strongest inhibitory activity (IC

Indexed as

1-Deoxynojirimycinalpha-GlucosidasesFlavonoidsGlycoside Hydrolase InhibitorsBinding SitesCatechinDrug SynergismKineticsMolecular Docking Simulation1-Deoxynojirimycinalpha-GlucosidasesCatechinFlavonoidsGlycoside Hydrolase Inhibitorsallosteric modulation(+)-catechinDNJsynergistic inhibitionα-Glucosidase

Identifiers

PMID42653988

DOI10.3390/molecules31162907

PMCPMC13515698

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.