Evidence map›Paper›PMID 42654084›Full record

ReviewPharmaceutics2026

Exploring the Antimicrobial Efficacy of Graphene Oxide: Key Mechanisms and Future Directions.

Yuezi Li, Zhihong Ke, Bilan Deng, Ying Chen, Xundong Lin, Aijie Chen, Weihong Guo, Xiaoli Feng

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuezi LiStomatology Hospital, School of Stomatology, Southern Medical University, Guangzhou 510515, China.
Zhihong KeDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Bilan DengStomatology Hospital, School of Stomatology, Southern Medical University, Guangzhou 510515, China.
Ying ChenDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xundong LinDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Aijie ChenStomatology Hospital, School of Stomatology, Southern Medical University, Guangzhou 510515, China.
Weihong GuoDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xiaoli FengStomatology Hospital, School of Stomatology, Southern Medical University, Guangzhou 510515, China.

Funding

Characteristic and Innovative Projects of Common Colleges in Guangdong Province 2024KTSCX071Guangdong Basic and Applied Basic Research Foundation 2025A1515011805Medical Scientific Research Foundation of Guangdong Province of China A2020131National Natural Science Foundation of China 82401178; 82001298the Nature Science Foundation of Guangdong Province 2024A1515030269
6 · The paper itself

Abstract

The inappropriate utilization of traditional antimicrobials has expedited the development of multidrug-resistant bacterial strains, thereby generating an urgent demand for innovative, safe, and efficacious alternatives. Graphene oxide (GO), characterized by its distinctive physicochemical properties, holds significant potential for a wide range of biomedical applications, such as the prevention of oral diseases, periodontal therapy, control of gastrointestinal infections, wound healing, antibacterial therapy for the respiratory tract, and management of urogenital infections. The antimicrobial mechanisms of GO include physical disruption of microbial membranes, induction of reactive oxygen species (ROS), and its role as a photosensitizer. Moreover, improving the dispersion, stability, release behavior, and reusability of GO-based composites can markedly enhance their effectiveness. The antimicrobial activity of GO is further modulated by its physicochemical properties, synthesis methods, bacterial characteristics, and environmental conditions, while potential synergistic or antagonistic interactions remain to be elucidated. This review synthesizes recent advancements in GO-based antimicrobial strategies, elucidates key mechanisms and influencing factors, and addresses major challenges and future research directions, with the objective of facilitating the clinical translation of GO as a next-generation antimicrobial material.

Indexed as

antibacterial dressingsantibiotic-resistant bacteriacaries preventiongastrointestinal infectiongraphene oxideoxidative stressphotothermal therapy

Identifiers

PMID42654084
PMCPMC13516088

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.