ArticleNutrients2026
The Effect of an Essential Amino Acid Supplement on Muscle Performance and Inflammation in an Animal Model of Overtraining.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
Funding
Abstract
BACKGROUND/
objectivesOvertraining (OT) syndrome occurs when an athlete's training load exceeds the athlete's ability to recover, leading to a performance decrement. The use of nutritional interventions to increase resiliency to OT is a topic of interest for maximizing performance adaptations. The purpose of this study was to determine whether an essential amino acid (EAA) supplementation administered intraperitoneally and orally can mitigate performance decrements and inflammatory responses in an animal model of resistance training-induced overtraining.
methodsThirty-two C57BL/6J mice were randomly assigned to four groups (n = 8 per group). One group served as a control (CTL), while the other three groups performed a 5-week resistance training ladder climb program. One group trained three days per week for the duration of the program (RT), while the training frequency of the other two groups doubled to six days per week to cause the OT stress. One group of animals were provided with EAA (RTOEAA), while the other received a sham (RTO). Changes (∆) in maximal carrying load (MCL) were assessed.
resultsRTO experienced a greater decrease in ∆MCL than RT (
conclusionsResults demonstrated that EAA supplementation was able to increase resiliency and reduce the inflammatory response to the volume overload stress.
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