Evidence map›Paper›PMID 42655785›Full record

ArticleVeterinary sciences2026

Eicosapentaenoic Acid (EPA) Alleviates Oxidative Stress and Inflammatory Responses in Canine Ileal Epithelial Cells.

Xiaoyue Yuan, Xizhu Zhu, Chuyang Zhu, Yunhan Wang, Chenhui Li, Minghua Yu, Fanfan Meng, Ping Hu, Haoyu Liu, Qu Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoyue YuanLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xizhu ZhuLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Chuyang ZhuLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Yunhan WangLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Chenhui LiLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Minghua YuYangzhou Weike Bio-Engineering Co., Ltd., Sinopharm Group, Yangzhou 225127, China.
Fanfan MengLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Ping HuLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Haoyu LiuLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-8529-1147
Qu ChenLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-0375-5970
Demin CaiLaboratory of Animal Physiology and Molecular Nutrition, Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-0500-5292

Funding

Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX25_4057
6 · The paper itself

Abstract

Fueled by the rapid growth of the global companion animal industry, the development of nutritional additives for improving canine intestinal health has emerged as a prominent research area in pet nutrition. Excessive reactive oxygen species accumulation triggers severe oxidative stress, inducing intestinal inflammation, abnormal epithelial senescence, and tight junction destruction to damage intestinal mucosal integrity. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have proven antioxidative and anti-inflammatory potency, yet divergent functions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on canine ileal epithelial cells (cIECs) remain unclear. Here, an H

Indexed as

canine ileal epithelial cellscellular senescenceeicosapentaenoic acidintestinal barrieroxidative stress

Identifiers

PMID42655785
PMCPMC13517765

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.