ArticleCancer medicine2026
UTMD Suppresses CSF-1 to Drive Macrophage-Mediated Ferroptosis in Papillary Thyroid Carcinoma.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
The tumor microenvironment (TME) of Papillary Thyroid Carcinoma (PTC), particularly the role of tumor-associated macrophages (TAMs), contributes to therapeutic resistance. This study investigated whether ultrasound-targeted microbubble destruction (UTMD), a non-invasive physical modality, could reprogram the TME through modulation of TAMs and induction of ferroptosis. Transcriptomic profiling identified CSF-1 as a top target suppressed by UTMD, which was validated by ELISA, Western blot, and qRT-PCR. UTMD time-dependently inhibited CSF-1 expression and secretion, consequently attenuating PTC-induced M2 macrophage polarization as evidenced by decreased CD206
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