ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2026
[Study on the effect of superficial layer damage on cartilage retention performance].
Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The superficial layer of articular cartilage acts as a critical physical barrier for joint homeostasis, and its damage is a hallmark of early osteoarthritis. To investigate the effect of superficial layer injury on solute permeation and retention in cartilage, two injury models were established using isolated porcine cartilage: chymotrypsin digestion (mucus layer injury) and physical abrasion (10% removal of the superficial layer). Rhodamine B (479 Da) and rhodamine-labeled dextrans (40 kDa, 150 kDa) were used as tracers. Combined with a custom-built permeation device and laser scanning confocal microscopy, solute transport behaviors under different injury degrees were analyzed. The results showed that superficial layer injury significantly impaired the barrier function, with retention concentrations increasing as injury severity rose. Solutes with lower molecular weights migrated more rapidly and exhibited higher retention levels. The peak solute concentration was localized in the superficial layer of normal cartilage but shifted toward the middle layer after injury. This study demonstrates that superficial layer integrity is essential for regulating cartilage solute transport, providing experimental evidence for understanding substance transport disorders in early cartilage degeneration of osteoarthritis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.