Evidence map›Paper›PMID 42656493›Full record

ArticleFrontiers in neuroscience2026

Assessing microglial phagocytosis of apoptotic neurons

Anthony Mukwaya, Zhuoran Yin, Ryan Yarcusko, George Baldwin, Nasir Uddin, Harshini Venkat, Yixi Xue, Natalia S Van Arnam, Hio Tong Kam, Dong Feng Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anthony Mukwaya *Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Zhuoran Yin *Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Ryan Yarcusko *Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
George BaldwinDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Nasir UddinDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Harshini VenkatDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Yixi XueDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Natalia S Van ArnamDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Hio Tong KamDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Dong Feng ChenDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Susanne KrasemannInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anton LennikovDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.
Milica A MargetaDepartment of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, United States.

Funding

Mechanisms of microglial neuroinflammatory response in glaucomaR01EY035312 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Milica Margeta · 2023 to 2026
$1.9M
NEI NIH HHS R01 EY035312
6 · The paper itself

Abstract

Microglia are the resident immune cells of the central nervous system, responsible for defending against infections, responding to tissue damage, and maintaining homeostasis. Dysregulation of their phagocytic activity has been implicated in many neurodegenerative diseases of the brain and the eye, including Alzheimer's disease, multiple sclerosis, glaucoma, and age-related macular degeneration. Past work has shown that brain and retinal microglia switch to a disease-associated molecular phenotype (DAM) following phagocytosis of apoptotic neurons

Indexed as

apoptosisin vitromicrogliaphagocytosisphosphatidylserine

Identifiers

PMID42656493
PMCPMC13506744

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.