Evidence map›Paper›PMID 42656731›Full record

ArticleFrontiers in molecular neuroscience2026

Investigating the role of EFhd2 protein in modulating tau pathology in a tauopathy mouse model.

Ahlam S Soliman, Andrew Umstead, Irving E Vega

Abstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahlam S SolimanDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States.
Andrew UmsteadDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States.
Irving E VegaDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States.

Funding

Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
NIA NIH HHS P30 AG072931
6 · The paper itself

Abstract

Accumulation of abnormally aggregated tau is the main pathological hallmark in tauopathies, including Alzheimer's disease (AD). Increasing evidence suggests that pretangle oligomeric tau aggregates exert neurotoxicity, while neurofibrillary tangles (NFTs) may represent less toxic structures that possibly delay cellular demise. A multitude of

Indexed as

EFhd2mouse modelneurofibrillary tanglesoligomerstautauopathies

Identifiers

PMID42656731
PMCPMC13506852

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.