Evidence map›Paper›PMID 42656813›Full record

ArticleMolecular therapy. Nucleic acids2026

Exon-skipping antisense oligonucleotides for H3.3K27M-altered diffuse midline glioma therapy.

Lucia Yang, Qian Zhang, John E Wilkinson, Shivani Deshpande, Adrian R Krainer

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lucia YangCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Qian ZhangCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
John E WilkinsonDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Shivani DeshpandeCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Adrian R KrainerCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
Inducing H3F3A exon skipping with antisense oligonucleotides as an approach to treat diffuse intrinsic pontine gliomaF30CA281196 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Lucia Yang · 2023 to 2026
$184k
NCI NIH HHS F30 CA281196NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA045508NIGMS NIH HHS T32 GM008444
6 · The paper itself

Abstract

Diffuse midline gliomas (DMGs) are a deadly class of pediatric high-grade brain cancers. Approximately 80% of pontine DMGs feature a dominant, somatic, heterozygous point mutation in the non-canonical histone H3.3-coding gene

Indexed as

antisense oligonucleotidesASOsexon skippingH3K27MMT: Oligonucleotides: Therapies and Applicationspediatric gliomaRNA

Identifiers

PMID42656813
PMCPMC13506960

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.