ReviewFrontiers in medicine2026
Topical regimens for the management of uremic pruritus.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uremic pruritus (UP), also known as chronic kidney disease-associated pruritus, is a distressing condition affecting patients with end-stage renal disease. Characterized by persistent itching, it significantly impacts patients' quality of life, leading to sleep disturbances, emotional distress, and decreased overall well-being. Although the exact pathophysiology remains uncertain, immune dysregulation, reduced stratum corneum hydration, and altered neurogenic inflammation contribute to UP. Consequently, treating UP poses a significant challenge. Among therapeutic regimens, topical regimens have been shown to effectively alleviate UP. Various topical formulations, including urea-based, physiological lipids, natural oils, capsaicin, anesthetics and glycerin-containing emollients, have demonstrated benefits in amelioration of pruritic symptoms. Clinical studies suggest that consistent application of emollients can minimize skin dryness and relieve pruritus. This review summarizes key clinical findings on the topical therapeutic regimens for UP.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.