Evidence map›Paper›PMID 42657920›Full record

ArticleThoracic cancer2026

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF-α/NF-κB Signaling and AIM2 Inflammasome Activation.

Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kairui ZhuDepartment of Thoracic Surgery, Yantaishan Hospital Affiliated to Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.ORCID https://orcid.org/0009-0002-3374-1318
Yulong MuDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Zhenguo SuDepartment of Clinical Laboratory, The Second Medical College of Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Zhen YueDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Dongyang WuDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Guiwu QuDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Chenyang JiangDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.ORCID https://orcid.org/0009-0002-1108-8047
Qing LiDepartment of Oncology, Yantaishan Hospital Affiliated to Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Youjie LiDepartment of Biochemistry and Molecular Biology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.
Ning XieDepartment of Thoracic Surgery, Yantaishan Hospital Affiliated to Shandong Medical and Pharmaceutical University, Yantai, Shandong, China.

Funding

Shandong Medical and Pharmaceutical University BZMUSPKL-2025-19Shandong Provincial Natural Science Foundation ZR2023MH223Yantai Municipal Science and Technology Bureau 2024YD025
6 · The paper itself

Abstract

backgroundPyroptosis-related signaling contributes to lung adenocarcinoma (LUAD) progression and prognosis. Apigenin (AP) has anti-inflammatory and cytoprotective properties, but its effects on pyroptosis-associated signaling in injured LUAD cells remain unclear.

methodsA549 cells were treated with carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and ferrous sulfate (FeSO

resultsCCCP/FeSO

conclusionAP attenuated CCCP/FeSO

Indexed as

Adenocarcinoma of LungApigeninDNA-Binding ProteinsInflammasomesLung NeoplasmsNF-kappa BPyroptosisTumor Necrosis Factor-alphaA549 CellsHumansSignal TransductionAIM2 protein, humanApigeninDNA-Binding ProteinsInflammasomesNF-kappa BTumor Necrosis Factor-alphaAIM2 inflammasomeapigeninlung adenocarcinomaNF‐κB signalingpyroptosis

Identifiers

PMID42657920
PMCPMC13520787

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.