Evidence map›Paper›PMID 42658299›Full record

ArticleJournal of computer-aided molecular design2026

Structure-based discovery of diphenylpyrazines as disruptors of the Skp2-Cks1 protein-protein interaction: computational insights and biochemical validation.

Emadeldin M Kamel, Ahmed A Allam, Hassan A Rudayni, Sarah I Othman, Fahad M Alshabrmi, Faris F Aba Alkhayl, Al Mokhtar Lamsabhi

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emadeldin M KamelChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. emad.abdelhameed@science.bsu.edu.eg.ORCID 0000-0002-1279-9564
Ahmed A AllamDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.
Hassan A RudayniDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.
Sarah I OthmanDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, 11671, Riyadh, Saudi Arabia.
Fahad M AlshabrmiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452, Buraydah, Saudi Arabia.
Faris F Aba AlkhaylDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452, Buraydah, Saudi Arabia.
Al Mokhtar LamsabhiDepartamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Universidad Autónoma de Madrid, Módulo 13, 28049, Madrid, Spain.

Funding

Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University PNURSP2026R5Ministerio de Ciencia, Innovación y Universidades PID2023-150717NB-I00 (MICINN)
6 · The paper itself

Abstract

The Skp2-Cks1 protein-protein interaction is essential for recognition of phosphorylated p27 and contributes to SCF

Indexed as

Antineoplastic AgentsCDC2-CDC28 KinasesPyrazinesS-Phase Kinase-Associated ProteinsBinding SitesDrug DiscoveryHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingStructure-Activity RelationshipAntineoplastic AgentsCDC2-CDC28 KinasesCKS1B protein, humanLigandsPyrazinesSKP2 protein, humanS-Phase Kinase-Associated ProteinsAnticancer drug discoveryMD simulationMM/PBSAProtein–protein interactionSkp2–Cks1

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.