ArticleNeurochemical research2026
Prednisone Exposure During Pregnancy Increases Susceptibility to Epilepsy in Adult Offspring Mice.
Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
Prenatal glucocorticoid exposure is associated with multiple long-term health risks in offspring. Prednisone is the most commonly used oral glucocorticoid. Although prior studies have shown that prenatal prednisone exposure (PPE) induces renal abnormalities in offspring rats and genital developmental abnormalities in offspring mice, its effects on brain development remain poorly understood. Our results showed that PPE impairs the proliferation and differentiation of neural progenitor cell, reduces neurogenesis, induces synaptic dysfunction, and affects microglial proliferation in offspring mice. These impairments were observed in female offspring during gestational days 0 to 9 (GD0-9) and GD0-18, whereas in male offspring, they were observed during GD0-18. We further identified that transient receptor potential vanilloid 1 (TRPV1) is upregulated in PPE offspring mice, and the epileptic phenotype was significantly attenuated in TRPV1
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Registered trials
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