Evidence map›Paper›PMID 42658384›Full record

ReviewCurrent cardiology reports2026

Antiarrhythmic Drug Therapy in Cardiomyopathies: A Comparative Synthesis of Guidelines and Consensus Documents.

Andrea Palermi, Massimo Di Marco, Silvio Saraullo, Roberta Magnano, Laura Pezzi, Davide Rossi, Giulia Renda, Sabina Gallina, Gianfranco Sinagra, Marco Merlo

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea PalermiDepartment of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, Via L. Polacchi 11, 66100, Chieti, Italy. apalermi96@gmail.com.ORCID http://orcid.org/0009-0006-0101-4019
Massimo Di MarcoCardiology and ICCU Department, Santo Spirito Hospital, Pescara, 65124, Italy.
Silvio SaraulloDepartment of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, Via L. Polacchi 11, 66100, Chieti, Italy.
Roberta MagnanoCardiology and ICCU Department, Santo Spirito Hospital, Pescara, 65124, Italy.
Laura PezziCardiology and ICCU Department, Santo Spirito Hospital, Pescara, 65124, Italy.
Davide RossiCardiology and ICCU Department, Santo Spirito Hospital, Pescara, 65124, Italy.
Giulia RendaDepartment of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, Via L. Polacchi 11, 66100, Chieti, Italy.
Sabina GallinaDepartment of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, Via L. Polacchi 11, 66100, Chieti, Italy.
Gianfranco SinagraCentre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Trieste, Italy.
Marco MerloCentre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewAntiarrhythmic drug therapy in cardiomyopathies remains challenging because arrhythmic risk, drug efficacy, and pro-arrhythmic vulnerability vary substantially across phenotypes. This review summarizes contemporary guideline and consensus recommendations on antiarrhythmic drug use in hypertrophic, dilated, non-dilated left ventricular, and arrhythmogenic cardiomyopathies. RECENT

findingsRecent guidelines increasingly emphasize phenotype-oriented arrhythmia management, but specific recommendations for antiarrhythmic drug therapy remain fragmented. Beta-blockers and amiodarone are the most consistently recommended agents in structural heart disease, whereas class I drugs are generally restricted. Evidence is strongest for hypertrophic and arrhythmogenic cardiomyopathies, while recommendations for dilated and non-dilated left ventricular cardiomyopathies are largely extrapolated from broader heart failure populations. Antiarrhythmic drugs are mainly used to reduce arrhythmic burden, symptoms, and implantable cardioverter-defibrillator therapies rather than to improve survival. Future studies should define phenotype-specific strategies based on ventricular function, myocardial scar, genotype, and clinical context.

Indexed as

Anti-Arrhythmia AgentsArrhythmias, CardiacCardiomyopathiesAdrenergic beta-AntagonistsAmiodaroneDefibrillators, ImplantableHumansPractice Guidelines as TopicAdrenergic beta-AntagonistsAmiodaroneAnti-Arrhythmia AgentsAntiarrhythmic drugsArrhythmogenic cardiomyopathyCardiomyopathiesDilated cardiomyopathyHypertrophic cardiomyopathyVentricular arrhythmias

Identifiers

PMID42658384
PMCPMC13521998

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.