Evidence map›Paper›PMID 42658761›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

RNF213-dependent lytic destruction of

Mary S Dickinson, Stephen C Walsh, Robert J Bastidas, Raphael H Valdivia, Jörn Coers

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mary S DickinsonDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-7227-9640
Stephen C WalshDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Robert J BastidasDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC 27710.
Raphael H ValdiviaDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0003-0961-073X
Jörn CoersDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-8707-4608

Funding

IRGM-driven host responses to Chlamydia trachomatis infectionsR01AI103197 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2013 to 2023
$4.2M
Functional characterization of early Chlamydia effectorsR01AI134891 · NIAID · DUKE UNIVERSITY · PI VALDIVIA, RAPHAEL H · 2018 to 2022
$2.4M
Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatisR37AI103197 · NIAID · DUKE UNIVERSITY · PI Jorn Coers · 2024 to 2026
$1.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI103197HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI134891NIAID NIH HHS R01 AI103197NIAID NIH HHS R01 AI134891NIAID NIH HHS R37 AI103197
6 · The paper itself

Abstract

The cytokine gamma-interferon promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathogens including the obligate intracellular bacterium

Indexed as

Chlamydia InfectionsChlamydia trachomatisUbiquitin-Protein LigasesVacuolesAutophagyCell DeathHeLa CellsHost-Pathogen InteractionsHumansUbiquitinationUbiquitin-Protein Ligasesautophagycell deathChlamydiainnate immunityinterferon

Identifiers

PMID42658761
PMCPMC13523078

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.