Ultrasound-assisted extraction of Allium macrostemon Bunge polysaccharides: optimization of extraction process, structural characterization and immunomodulatory effects.

Jingjing Yao, Anting Ma, Yusang Chen, Yujia Zhang, Xiuyu Tang, Senlin Shi, Xi Han, Ting Zhang

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Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Jingjing YaoSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Anting MaSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Yusang ChenSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Yujia ZhangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Xiuyu TangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Senlin ShiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Xi HanSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: 20241149@zcmu.edu.cn.

Ting ZhangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: zhangting55@zcmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The traditional Chinese medicinal herb Allium macrostemon Bunge (AMB) possessed both nutritional value for consumption and health benefits. Although it was extensively used in many areas, studies on its polysaccharide fractions were still limited at present. In this study, ultrasonic-assisted extraction was adopted to prepare Allium macrostemon Bunge polysaccharides (AMBP), and three strategies including Box-Behnken design (BBD), genetic algorithm optimized back propagation neural network (GA-BP), and gradient boosting decision tree (GBDT) were separately employed to optimize the extraction parameters. Experimental results demonstrated that the GA-BP model exhibited superior data fitting and prediction performance with remarkably higher prediction accuracy compared with the BBD and GBDT models. The coefficient of determination (R

Indexed as

Allium macrostemon Bunge polysaccharideImmunomodulatory activityStructural characterizationUltrasonic-assisted extraction

Identifiers

PMID42659850

DOI10.1016/j.ultsonch.2026.108023

PMCPMC13544109

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.