Evidence map›Paper›PMID 42660922›Full record

ArticleNature communications2026

The response regulator BqsR/CarR controls Fe

Alexander Paredes, Mackenzie Hull, Harvinder Singh, Darryn Greene, Ahmed O Tajudeen, Aya Kubo, Sara Patamawenu, Rachel Kramer, Janae B Brown, Kelly N Chacón and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexander Paredes *Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Mackenzie Hull *Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
Harvinder SinghDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Darryn GreeneDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Ahmed O TajudeenDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
Aya KuboDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
Sara PatamawenuDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Rachel KramerDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Janae B BrownDepartment of Chemistry and Biochemistry, Spelman College, Atlanta, GA, USA.
Kelly N ChacónDepartment of Chemistry, Reed College, Portland, OR, USA.ORCID 0000-0003-1332-7283
Marianna A PatrauchanDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
Aaron T SmithDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA. smitha@umbc.edu.ORCID 0000-0002-9332-8683

Funding

Deciphering the Mechanisms of Pathogenic Ferrous Iron Acquisition and Eukaryotic Post-Translational ArginylationR35GM133497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI Aaron T Smith · 2019 to 2026
$2.9M
Calcium signaling controls Pseudomonas aeruginosa invasion and adaptation to the host intracellular environmentR15GM124670 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI PATRAUCHAN, MARIANNA M. A. · 2017 to 2023
$1.1M
Graduate Training at The Chemistry Biology InterfaceT32GM158458 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI Steven Fletcher, Aaron T Smith · 2025 to 2026
$564k
Cystic Fibrosis Foundation (CF Foundation) CFF-005124P222Howard Hughes Medical Institute (HHMI) GT15765NIGMS NIH HHS R15 GM124670NIGMS NIH HHS R35 GM133497NIGMS NIH HHS T32 GM158458NIGMS NIH National Institutes of Health, National Institute of General Medical Sciences P30-GM133894U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM124670U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM133497U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM158458
6 · The paper itself

Abstract

Pseudomonas aeruginosa is a ubiquitous, Gram-negative bacterium that forms biofilms and is responsible for antibiotic-resistant hospital-acquired infections in humans. The P. aeruginosa BqsRS two-component system regulates biofilm formation and dispersal by sensing extracytoplasmic Fe

Indexed as

Bacterial ProteinsIronPseudomonas aeruginosaBiofilmsGene Expression Regulation, BacterialOperonPromoter Regions, GeneticProtein BindingBacterial ProteinsIron

Identifiers

PMID42660922
PMCPMC13522522

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.