ArticleBrain communications2026
NOR1 loss relates to inflammation and biological ageing in multiple sclerosis motor cortex.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cortical neurodegeneration and glial activation are major drivers of disability progression in multiple sclerosis, but the molecular mechanisms underlying these processes remain poorly defined. Members of the NR4A nuclear receptor family are stress-responsive transcription factors that regulate neuronal survival, inflammatory signalling and cellular adaptation to metabolic and oxidative stress. In particular, neuron-derived orphan receptor 1 (NR4A3) has been implicated in neuroprotective and stress-adaptive responses in other neurological conditions, but its role in multiple sclerosis has not been investigated. Given its dual involvement in neuronal stress regulation and inflammatory modulation, neuron-derived orphan receptor 1 represents a plausible molecular link between chronic neuroinflammation, biological ageing and cortical neurodegeneration in multiple sclerosis. Here, we examined neuron-derived orphan receptor 1 expression in the motor cortex of post-mortem multiple sclerosis (
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