ArticleBlood vessels, thrombosis & hemostasis2026
Platelet miR-144-5p regulates COX-1/2 expression and modulates aspirin response in patients with cardiometabolic risk.
Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Interindividual variability in response to low-dose aspirin (acetylsalicylic acid; ASA) contributes to residual platelet activation and thrombotic risk. Platelet microRNAs (miRNAs) may modulate ASA pharmacodynamics, but their mechanistic role remains unclear. We investigated whether platelet miR-144-5p regulates cyclooxygenase 1/2 (COX-1/2) expression and modulates ASA response in patients with cardiometabolic disease. Two hundred ASA- treated patients were stratified into tertiles of serum thromboxane B
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