Evidence map›Paper›PMID 42662604›Full record

ArticleACS omega2026

Reversible Charge-Mediated Capture and Release of Extracellular Vesicles Using Giant Unilamellar Vesicles.

Marinella Pinelli, Gabriele Schiavi, Dalia Tarantino, Luca Valer, Martina Cortese, Michela Notarangelo, Miriam Romano, Annalisa Radeghieri, Lucia Paolini, Paolo Bergese and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marinella PinelliCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.ORCID https://orcid.org/0000-0001-8045-8772
Gabriele SchiaviCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Dalia TarantinoCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Luca ValerCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Martina CorteseCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Michela NotarangeloCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Miriam RomanoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
Annalisa RadeghieriDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.ORCID https://orcid.org/0000-0003-2737-1090
Lucia PaoliniDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia 25123, Italy.ORCID https://orcid.org/0000-0002-4410-5272
Paolo BergeseDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.ORCID https://orcid.org/0000-0002-4652-2168
Vito G D'AgostinoCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.
Martin M HanczycCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.ORCID https://orcid.org/0000-0002-5453-2139
Silvia HollerCellular Computational and Integrative Biology Department, CIBIO, University of Trento, Via Sommarive 9, Povo, 38123, Italy.ORCID https://orcid.org/0000-0002-2572-8677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) play crucial roles in intercellular communication and represent promising therapeutic vehicles, yet current isolation and manipulation methods often irreversibly alter their properties. This study presents a charge-mediated approach for the reversible interaction and release of EVs using Giant Unilamellar Vesicles (GUVs) exploiting tailored surface charges. Negatively charged EVs can be selectively bound through electrostatic interactions with positively charged GUVs, forming stable aggregates. Critically, these interactions are reversible upon the introduction of a negatively charged moiety, oleic acid, which disaggregates the complexes and releases the vesicles. Selective fusion events between oppositely charged GUVs allow modulation of internal composition, while GUVs-EVs interactions remain nonfusogenic. This reversible, charge-based platform offers advantages over current EVs' capture methods, including simplicity, low cost, and the potential for a separation method without permanent labeling.

Identifiers

PMID42662604
PMCPMC13520013

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.