Evidence map›Paper›PMID 42662609›Full record

ArticleACS omega2026

Structural Basis and Conformational Switching of Capture-SELEX Aptamers for Designing Equol Sensors.

Tamaki Endoh, Hidenobu Yaku, Peter Podbevsek, Janez Plavec, Naoki Sugimoto

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PubMed Full text at PMC Publisher
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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tamaki EndohFrontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 minatojima-minamimachi, Kobe 650-0047, Japan.ORCID https://orcid.org/0000-0001-5272-5896
Hidenobu YakuPanasonic Holdings Corporation, 3-1-1 Yagumo-naka-machi, Moriguchi City, Osaka 570-8501, Japan.
Peter PodbevsekSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana SI-1000, Slovenia.ORCID https://orcid.org/0000-0002-2563-4507
Janez PlavecSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana SI-1000, Slovenia.ORCID https://orcid.org/0000-0003-1570-8602
Naoki SugimotoFrontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 minatojima-minamimachi, Kobe 650-0047, Japan.ORCID https://orcid.org/0000-0003-2928-7028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expanding healthy life expectancy requires technologies for continuous and noninvasive health monitoring. Sensors detecting health-related biomarkers in urine can be used for such applications. Aptamers are nucleic acids that interact with biomolecules through the formation of unique tertiary structures, some of which undergo target-induced conformational switching. The structural and dynamic properties of aptamers can be utilized for constructing sensors. In this study, DNA aptamers targeting equol, a gut microbiota-derived metabolite with various health benefits, were obtained by Capture-SELEX. Highly enriched 5 aptamers, Eq1 to Eq5, exhibited equilibrium association constants more than 10

Identifiers

PMID42662609
PMCPMC13520023

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.