ArticleSleep advances : a journal of the Sleep Research Society2026
Feasibility of a contactless, self-directed, home-based dim-light melatonin onset protocol: the Circadia pilot study.
Article in Sleep advances : a journal of the Sleep Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.Current sleep medicine reports · 2025Review
- Feasibility and acceptability of self-directed, remote dim-light melatonin onset collection in pediatric patients diagnosed with chronic pain.Frontiers in sleep · 2025Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
Abstract
Study Objectives: To test the feasibility of a self-directed, in-home, contactless salivary dim light melatonin onset (DLMO) assessment protocol to remotely measure endogenous circadian phase in participants with circadian rhythm disorders and healthy controls. Materials and Methods: The 4-6-week protocol involved sleep, activity, and light tracking, sleep diaries, questionnaires, and two self-directed at-home salivary sample collections for DLMO one week apart with objective compliance measures. Individuals participated remotely using an online portal and received a mailed kit. The study population included five cases with Circadian-Rhythm Sleep-Wake Disorders and five controls ages 27-63. Results: Salivary DLMO times could be calculated for 14/20 assessments, resulting in 8/10 participants with at least 1 valid DLMO and 6/10 having valid DLMOs for both. Failures in DLMOs resulted from compliance errors (eg, bright light levels) or consistently below/above threshold melatonin levels. After completing the DLMO collections, 70% of participants felt confident after completing DLMO 1, while 90% felt confident after DLMO 2. DLMO occurred on average at 24.08 hours (SEM = 1.10 hours) for four participants with Delayed Sleep Wake Phase Disorder, and at 21.37 hours (SEM = 0.71 hours) for five controls. The first and second DLMOs were strongly correlated ( Conclusions: Our results indicate that contactless, self-directed, at-home DLMO assessments are feasible, reliable, and capable of detecting clinically relevant differences in circadian timing. The current protocol may serve as a framework to reliably and scalably assess circadian phase in both clinical and general populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.