ArticleMolecular therapy. Nucleic acids2026
The lncRNA, CyKILRb acts as a ceRNA for tumor suppressive microRNA to augment oncogenic phenotype via induction of PIK3R2/PI
Xiujie Xie, H Patrick Macknight, Barbara Dziegielewska, Amy L Lu, Ngoc Thanh Vu, Charles E Chalfant
Abstract read
In one paragraphArticle in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Xiujie XieDepartment of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
H Patrick MacknightDepartment of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
Barbara DziegielewskaDepartment of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
Amy L LuDepartment of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
Ngoc Thanh VuDepartment of Applied Chemistry, School of Biotechnology, International University, Ho Chi Minh City, Vietnam.
Charles E ChalfantDepartment of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
Funding
Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1MTissue Repository and Animal Models CoreP01CA171983 · NCI · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E. · 2013 to 2024
$19.9MProject 3P01CA302570 · NCI · UNIVERSITY OF VIRGINIA · PI Thomas P. Loughran · 2025 to 2026
$7.8MThe roles of ceramide and its derivatives in A. phagocytophilum pathogenesisR01AI139072 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARLES E. CHALFANT, Jason A Carlyon · 2018 to 2026
$5.7MiPLA2beta-mediated alternative splicing and -cell death in type 1 diabetesR01DK126444 · NIDDK · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., EIZIRIK, DECIO LAKS · 2021 to 2024
$2.0MRegulation of ceramide-1-phosphate metabolism in cell signaling networksR01GM155691 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHARLES E. CHALFANT · 2025 to 2026
$707kBLRD VA I01 BX001792BLRD VA I01 BX006063NCI NIH HHS P01 CA171983NCI NIH HHS P01 CA302570NCI NIH HHS P30 CA044579NIAID NIH HHS R01 AI139072NIDDK NIH HHS R01 DK126444NIGMS NIH HHS R01 GM155691ORD VA I01 RD001334ORD VA IK6 RD002739
6 · The paper itselfAbstract
The lncRNA CyKILR produces two splice variants with antagonistic roles in lung tumorigenesis. While its nuclear counterpart functions as a tumor suppressor, we revealed that the cytoplasmic variant, CyKILRb, is a potent oncogenic driver that activates the PI
Indexed as
AKTCyKILRlong noncoding RNAsmicroRNAsmiR-3151-5pMT: non-coding RNAsnon-small cell lung cancersPI3KPIK3R2RNA splicing
Identifiers
PMID42662823
PMCPMC13520900
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