Evidence map›Paper›PMID 42662892›Full record

ArticleMolecular therapy. Oncology2026

Prevention of HNSCC by chewing gum delivery of enzymes/antimicrobials to reduce carcinogenic acetaldehyde produced by pathogenic microbes.

Geetanjali Wakade, Serena Chaolu Liu, Nhi Eliana Diep, Henry Daniell

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Geetanjali WakadeDepartment of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
Serena Chaolu LiuDepartment of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
Nhi Eliana DiepDepartment of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
Henry DaniellDepartment of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.

Funding

Oral immune modulatory therapy using antigens bioencapsulated in plant cellsR01HL107904 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DANIELL, HENRY · 2011 to 2023
$7.5M
NHLBI NIH HHS R01 HL107904
6 · The paper itself

Abstract

Acetaldehyde, a WHO Group 1 human carcinogen, produced by oral microbes, plays a critical role at the onset of head and neck squamous cell carcinoma (HNSCC).

Indexed as

alcocol and cancercandidiasiscarcinogenic metabolitesdysbiosishead and neck canceroral canceroral microbiomeoral molecular therapypathogenic bacteria

Identifiers

PMID42662892
PMCPMC13521093

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.