ArticleAmerican journal of physiology. Renal physiology2026
Renal single-nucleus transcriptomic of a new model of cardiovascular-kidney-metabolic syndrome in aging swine.
Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cardiovascular-kidney-metabolic (CKM) syndrome entails pathophysiological interactions among the heart, the kidneys, and metabolic derangements. The specific cell populations implicated in renal injury have yet to be identified. We leveraged a new model of CKM syndrome in aging swine and single-nucleus RNA sequencing (snRNA-seq) to investigate the renal cell-specific transcriptomic profile and set the stage for future testing of potential new targets. Aging pigs with CKM syndrome were studied for 14 wk. Kidneys were harvested, nuclei isolated, snRNA-seq performed, and UMAP plots generated using default parameters. Expression profiles of marker genes were visualized to define renal cell types, ranked by the number of differentially expressed genes (DEGs), and factored by the total number of cells per cell type. Top DEGs/cell type were visualized, and their protein expression was assessed in confirmatory studies. A total of 52,367 nuclei were analyzed. Thirty clusters were identified and filtered by canonical gene markers, revealing 20 renal cell types. Subsequent analysis of CKM syndrome kidneys showed that proximal tubular (PT) and immune (IM) cell subpopulations had 49.1% and 45.8% of cells with DEGs, respectively, which were mainly implicated in microtubule organization and age-related inflammation (
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