Evidence map›Paper›PMID 42664334›Full record

ArticleScience advances2026

A self-triggering and fully sustainable gastric device enabling long-acting oral delivery of macromolecules.

Chengbang Lu, Zede Yi, Hongyan Yuan, Haoying Wang, Kewen Lei, Weijie Li, Xianglin Wu, Weixuan Liu, Yunxiang Zhang, Teng Dong and 11 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Chengbang LuAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0009-0006-1117-1501
Zede YiAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0009-0003-7855-5575
Hongyan YuanShenzhen Hospital, University of Chinese Academy of Sciences, Shenzhen 518000, China.ORCID 0009-0000-7727-397X
Haoying WangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0002-9190-9978
Kewen LeiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-3586-682X
Weijie LiShenzhen Hospital, University of Chinese Academy of Sciences, Shenzhen 518000, China.ORCID 0009-0005-1042-3095
Xianglin WuShenzhen Hospital, University of Chinese Academy of Sciences, Shenzhen 518000, China.ORCID 0009-0009-4414-1968
Weixuan LiuDepartment of Materials Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8079-1089
Yunxiang ZhangAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0009-0002-3402-3887
Teng DongDepartment of Chemical Engineering, University College London, London WC1E 7JE, UK.ORCID 0000-0002-6881-2350
Kai WuAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0009-0006-2360-5768
Yaoben WangState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.ORCID 0009-0000-2784-026X
Shuquan CuiDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8764-0718
Yue ZhaoDepartment of Laboratory Medicine, Chongqing General Hospital School of Medicine Chongqing University, Chongqing 401147, China.ORCID 0009-0006-8862-8610
Yingning HeSchool of Physics and Optoelectronics, Xiangtan University, Xiangtan, Hunan 411105, China.ORCID 0000-0002-5873-4520
U Kei CheangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0002-2324-6391
Tian LiuSchool of Bioengineering and School of Physics, Dalian University of Technology, Dalian 116024, China.ORCID 0000-0001-9768-5496
Yancong ZhangAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0000-0002-2768-2975
Tianyuan CiSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yiyuan YangThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-1262-354X
Xiangyu LiangAgricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.ORCID 0000-0002-3663-8394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-acting oral delivery of macromolecular therapeutics remains difficult, as most oral delivery devices focus on improving gastrointestinal absorption but do not adequately address sustained drug release and frequent dosing. In parallel, many gastric-retentive systems rely on nondegradable structural components, raising concerns regarding retained-device burden and postuse medical waste. Here, we report a biodegradable oral capsule device for long-lasting drug delivery, termed the sustainable gastric self-triggered device (SGSTD), inspired by the stinging mechanism of

Indexed as

Drug Delivery SystemsMacromolecular SubstancesAdministration, OralAnimalsDelayed-Action PreparationsDrug LiberationGastric MucosaHumansInsulinStomachSwineDelayed-Action PreparationsInsulinMacromolecular Substances

Identifiers

PMID42664334
PMCPMC13524043

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.