In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Kohta TakahashiLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0009-0007-1466-9126 Nario TomishigeLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0000-0002-1266-5400 Gašper ŠolincDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana 1001, Slovenia.
James RaeInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID 0000-0003-0525-2154 Toshiyuki YamajiDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseases. Shinjuku-ku, 162-0052 Tokyo, Japan.
Frédéric PrzybillaLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0009-0009-2016-353X Ludovic RichertLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0000-0003-4479-5418 Nicolas HumbertLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0000-0002-0166-5608 Takefumi UemuraDepartment of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.ORCID 0000-0002-7643-2673 Thomas WollertLaboratoire de Biochimie Membranaire et Transport, UMR 3691 CNRS, Institut Pasteur, 75724 Paris, France.ORCID 0000-0001-9732-4789 Satoshi WaguriDepartment of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.ORCID 0000-0001-9919-7111 Kentaro HanadaDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseases. Shinjuku-ku, 162-0052 Tokyo, Japan.
Gregor AnderluhDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana 1001, Slovenia.ORCID 0000-0002-9916-8465 Robert G PartonInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID 0000-0002-7494-5248 Yves MélyLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0000-0001-7328-8269 Catherine TomasettoCNRS, Inserm, IGBMC UMR 7104-UMR-S 1258, Université de Strasbourg, F-67400 Illkirch, France.
Fabien AlpyCNRS, Inserm, IGBMC UMR 7104-UMR-S 1258, Université de Strasbourg, F-67400 Illkirch, France.ORCID 0000-0002-0526-0720 Toshihide KobayashiLaboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, F67401 Illkirch, France.ORCID 0000-0002-4811-7270 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. Here, we show that sphingomyelin (SM), typically confined to the lumen of the trans-Golgi network (TGN), is exposed on its cytoplasmic surface by the action of the Golgi-associated protein, Golgi-associated gamma-adaptin ear-containing adenosine 5'-diphosphate-ribosylation factor-binding protein 1 (GGA1). This exposure is driven by the GGA1 GAT domain, which induces lipid scrambling in a manner dependent on membrane curvature and cholesterol. SM exposure coincides with the exit of mannose 6-phosphate receptors from the TGN, a process essential for lysosomal enzyme trafficking. Furthermore, SM is transferred to autophagic membranes, where it facilitates autophagosome-lysosome fusion. These findings reveal a previously unrecognized role for lipid remodeling in membrane trafficking and autophagy.
Indexed as
Adaptor Proteins, Vesicular TransportAutophagyLysosomestrans-Golgi NetworkAnimalsAutophagosomesCholesterolHumansProtein TransportReceptor, IGF Type 2SphingomyelinsAdaptor Proteins, Vesicular TransportCholesterolGGA adaptor proteinsReceptor, IGF Type 2Sphingomyelins
Identifiers
PMID42664358
PMCPMC13524056
What Socratic holds
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