Evidence map›Paper›PMID 42666239›Full record

ArticleFrontiers in endocrinology2026

Secreted frizzled-related protein 3 is associated with metabolic disturbances in gestational diabetes.

Thor Ueland, Annika Elisabet Michelsen, Elisabeth Qvigstad, Marie Cecilie Paasche Roland, Ane Cecilie Westerberg, Trond Melbye Michelsen, Pål Aukrust, Jens Bollerslev, Tove Lekva

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Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Thor UelandResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Annika Elisabet MichelsenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Elisabeth QvigstadDept of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Marie Cecilie Paasche RolandDepartment of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Ane Cecilie WesterbergDepartment of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Trond Melbye MichelsenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Jens BollerslevInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Tove LekvaResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Secreted modulators of the Wingless (WNT) pathways are associated with cardiometabolic dysregulation. Among these, Dickkopf-1 (DKK1) and secreted frizzled-related protein-3 (sFRP3) are abundantly expressed in placental tissue and secreted into the maternal circulation. We hypothesized their plasma levels would be dysregulated in women with gestational diabetes mellitus (GDM) and correlate with indices of metabolic health. Methods: A total of 284 women during pregnancy and at 5 years postpartum participated in this longitudinal cohort study. Secreted Wnt modulators were analyzed by enzyme immunoassay 4 times during pregnancy and postpartum. Lipids and indices of glucose tolerance were assessed twice in pregnancy and at follow-up. Body composition and pulse wave velocity analysis was assessed at follow-up. Results: Our main findings: i) plasma DKK1 was lower throughout pregnancy in women with GDM. ii) sFRP3 was lower early in pregnancy in women with GDM and correlated with indices of obesity and adipose tissue related inflammation, insulin resistance, poor β-cell function and unfavorable lipid ratios. iii) low DKK1 during pregnancy was associated with higher aortic stiffness at follow-up. Conclusions: Low plasma sFRP3 during early pregnancy is associated with metabolic and inflammatory dysregulation while persistently low DKK1 may be associated with future cardiovascular disease risk in GDM pregnancies.

Indexed as

BiomarkersDiabetes, GestationalIntercellular Signaling Peptides and ProteinsAdultFemaleHumansInsulin ResistanceLongitudinal StudiesPregnancySecreted Frizzled-Related ProteinsBiomarkersDKK1 protein, humanIntercellular Signaling Peptides and ProteinsSecreted Frizzled-Related Proteinsaortic stiffnessDickkopf-1gestational diabetessecreted frizzled-related protein-3Wnt signaling

Identifiers

PMID42666239
PMCPMC13521849

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.