Evidence map›Paper›PMID 42666490›Full record

ArticleMedComm2026

SPR-UPLC-QTOF/MS-GNPS-Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor-Binding Small-Molecule Lead for Inflammatory Storm Intervention.

Yongqi Li, Weiguang Sun, Xingpiao Jin, Lanqin Li, Xiaotian Zhang, Pingping Fan, Yahui Huang, Chaohu Xiong, Jinsheng Wang, Jiangchun Wei and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yongqi LiHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Weiguang SunHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Xingpiao JinShanxi Provincial Innovation Center for Upper Gastrointestinal Cancer Research and Clinical Translation Heping Hospital Affiliated to Changzhi Medical College Changzhi China.
Lanqin LiDepartment of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Xiaotian ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Pingping FanHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Yahui HuangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Chaohu XiongHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Jinsheng WangShanxi Provincial Innovation Center for Upper Gastrointestinal Cancer Research and Clinical Translation Heping Hospital Affiliated to Changzhi Medical College Changzhi China.
Jiangchun WeiShanxi Provincial Innovation Center for Upper Gastrointestinal Cancer Research and Clinical Translation Heping Hospital Affiliated to Changzhi Medical College Changzhi China.
Yonghui ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Zhengxi HuHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study developed an integrated strategy combining surface plasmon resonance (SPR) for real-time biomolecular interaction analysis, ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) for compound profiling, and Global Natural Products Social Molecular Networking (GNPS)-based molecular networking for structural annotation in complex herbal systems. Using this platform, we identified hypermonol J (HPJ), a polycyclic polyprenylated acylphloroglucinol (PPAP), as a high-affinity small-molecule binder of tumor necrosis factor (TNF) (

Indexed as

acute lung injuryHypericum monogynumhypermonol Jpsoriasissurface plasmon resonance‐active ingredient recognition systemtumor necrosis factor

Identifiers

PMID42666490
PMCPMC13522848

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.