Evidence map›Paper›PMID 42666505›Full record

ArticleFrontiers in cellular and infection microbiology2026

Multicohort external validation of

Jing Wang, Ye Tao, Hua-Don Meng, Xiong-Fen Zhu, Xiu-Min Xu, Da-Wei Mi

Abstract readValidation Study
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing WangDepartment of Pediatric Dentistry, Hefei Stomatological Hospital, Hefei, Anhui, China.
Ye TaoAnhui Institute of Medicine Affiliated Stomatological Hospital, Hefei, Anhui, China.
Hua-Don MengAnhui Institute of Medicine, Hefei, Anhui, China.
Xiong-Fen ZhuAnhui Institute of Medicine, Hefei, Anhui, China.
Xiu-Min XuDepartment of Pediatric Dentistry, Hefei Stomatological Hospital, Hefei, Anhui, China.
Da-Wei MiDepartment of Stomatology, Suzhou Hospital of Anhui Medical University (Suzhou Municipal Hospital of Anhui Province), Suzhou, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the cross-cohort reproducibility of Methods: Public pediatric salivary 16S rRNA cohorts were analyzed using a discovery-primary external validation-second validation framework. Genus-level features were assessed after CLR transformation and covariate adjustment, with plaque microbiome, plaque transcriptome, and deep-caries dental pulp single-cell datasets used as supporting evidence layers. Results: In the discovery cohort, Conclusions:

Indexed as

Bacteria, AnaerobicBiomarkersDental CariesSalivaChildChild, PreschoolCohort StudiesDental PlaqueFemaleHumansLactobacillusMaleMicrobiotaReproducibility of ResultsRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16SAnaeroglobuschildhood cariesdental plaqueexternal validationsalivary microbiomesingle-celltranscriptome

Identifiers

PMID42666505
PMCPMC13522189

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.