ArticleAutophagy reports2026
Autophagy inhibition in pancreatic cancer: hope or hype?
Emma Guilbaud, Edna Cukierman, Igor Astsaturov, Lorenzo Galluzzi
Abstract read
In one paragraphArticle in Autophagy reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
4 authors.
Emma GuilbaudCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Edna CukiermanCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Igor AstsaturovCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Lorenzo GalluzziCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8MRadiation Effect on Immune Cells and the MicrobiomeU54CA274291 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph O Deasy · 2022 to 2026
$9.1MRefolding Mutant p53: A Strategy for Cancer Prevention in Li-Fraumeni SyndromeU54CA272686 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI MARGIE L. CLAPPER · 2022 to 2026
$8.3MPancreatic Cancer-Associated Fibroblasts: Function, Detection, and RegulationR01CA269660 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$3.1MTargeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancerR01CA271915 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Lorenzo Galluzzi · 2023 to 2026
$2.9MSynergistic targeting of cholesterol metabolism and EGFR signaling in cancerR01CA188430 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI ASTSATUROV, IGOR · 2014 to 2018
$1.9MOncogenic Synapses: cell-cell contacts enabling trogocytic-based metabolic interactions between pancreatic cancer and fibroblastic stromal cellsR21CA231252 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI ASTSATUROV, IGOR, CUKIERMAN, EDNA · 2019 to 2020
$437kRegulation of EGFR by SC4MOL- and NSDHL-Dependent TraffickingR21CA164205 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI ASTSATUROV, IGOR · 2012 to 2013
$413kNCI NIH HHS P30 CA006927NCI NIH HHS R01 CA188430NCI NIH HHS R01 CA269660NCI NIH HHS R01 CA271915NCI NIH HHS R21 CA164205NCI NIH HHS R21 CA231252NCI NIH HHS U54 CA272686NCI NIH HHS U54 CA274291
6 · The paper itselfAbstract
Autophagy promotes tumor progression and immune evasion by numerous mechanisms, representing a promising target for novel (immuno)therapeutic interventions in multiple oncological indications. An expanding literature, however, suggests that safely and effectively targeting autophagy in the clinic remains challenging, especially in populations as complex to manage as patients with pancreatic cancer.
Indexed as
Hydroxychloroquineimmune checkpoint inhibitorsMEKMHC class Itrametinibtype I interferon
Identifiers
PMID42666728
PMCPMC13524002
What Socratic holds
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