Evidence map›Paper›PMID 42666822›Full record

ArticleEuropean heart journal. Case reports2026

Resistant hypertension and epileptic seizures: a possible modulatory role of renal denervation-a case report.

Antonio Bustos-Merlo, Alberto Fajardo-Muñoz, Teresa Bretones-Del Pino, Eduardo Molina-Navarro, Fernando Jaén-Águila

Abstract readCase Reports
In one paragraph

Article in European heart journal. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonio Bustos-MerloDepartment of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 18014 Granada, Spain.ORCID https://orcid.org/0000-0001-5777-6596
Alberto Fajardo-MuñozDepartment of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 18014 Granada, Spain.
Teresa Bretones-Del PinoDepartment of Cardiology, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 18014 Granada, Spain.ORCID https://orcid.org/0000-0001-8344-0199
Eduardo Molina-NavarroDepartment of Cardiology, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 18014 Granada, Spain.
Fernando Jaén-ÁguilaDepartment of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas, 18014 Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Renal denervation (RDN) is an emerging therapy for selected patients with resistant hypertension. Its broader autonomic effects may extend beyond blood pressure regulation. Case summary: A 57-year-old man with resistant hypertension treated with six antihypertensive drugs and recurrent autonomic and generalized seizures underwent radiofrequency RDN. At 3 months, ambulatory blood pressure monitoring showed sustained improvement (24 h mean 139/87 mmHg), enabling therapy de-escalation. Generalized tonic-clonic seizures resolved, and autonomic/focal events markedly decreased without changes in antiepileptic medication. Discussion: This case illustrates a potential extrapressor effect of RDN mediated by modulation of sympathetic overactivity. Although causality cannot be drawn from a single case, the parallel neurological improvement supports exploring RDN's role in conditions involving autonomic dysregulation, including certain epileptic syndromes.

Indexed as

Autonomic epilepsyCase reportDrug-resistant seizuresRenal denervationResistant hypertensionSympathetic modulation

Identifiers

PMID42666822
PMCPMC13524317

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.