ArticleArchives of microbiology2026
"Edible plant-associated fungal endophytes as sources of bioactive specialized metabolites: antimicrobial and docking insights".
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endophytic fungi have emerged as prolific sources of structurally diverse and biologically potent specialized metabolites with significant therapeutic potential. In this study, endophytic fungi were isolated from three edible plant species: Raphanus sativus, Eruca sativa, and Allium porrum, to systematically assess their biodiversity and antimicrobial capabilities. A total of twenty-six fungal isolates were obtained, of which seven were prioritized for detailed morphological and functional characterization based on preliminary bioactivity screening. Among these, Fusarium oxysporum (A1/APFE1) and Aspergillus niger (E2/RSFE2) exhibited pronounced and broad-spectrum antimicrobial activity against clinically and agriculturally relevant pathogens, including Candida albicans (ATCC 10231), Pseudomonas aeruginosa (ATCC 27853), and Staphylococcus aureus (ATCC 29213), under both solid-state and submerged culture conditions. Phylogenetic characterizations for the two endophytic isolates were performed. Ethyl acetate extracts of these two strains were subjected to high-resolution LC-HR-ESI-MS metabolomic profiling, which demonstrated a chemically varied range of specialized metabolites, including terpenoids, polyketides, macrolides, and phenolics. Subsequent in silico molecular docking analyses highlighted specific metabolites with strong binding affinities to dihydrofolate reductase, providing mechanistic insights into the observed antimicrobial activity. Collectively, these results position F. oxysporum (A1/APFE1) and A. niger (E2/RSFE2) as promising candidates for the development of novel antimicrobial agents, highlighting the edible plant-associated endophytic fungi's unrealized medicinal potential.
Indexed as
Identifiers
42667376What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.