ArticleInternational ophthalmology2026
Neurotrophic effects of topical insulin in persistent epithelial defects.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
purposeTo evaluate the effect of topical insulin eye drops in promoting epithelial healing in patients with neurotrophic keratopathy (NK) and persistent epithelial defects (PED), and to assess their impact on corneal sensitivity as an indicator of neurotrophic function.
methodsThis retrospective study included 24 patients with PED unresponsive to standard medical and surgical treatment. Patients received topical insulin eye drops (1 IU/mL) every six hours for one month. Corneal sensitivity, measured with Cochet-Bonnet esthesiometer, and PED size were recorded at baseline, and at 1st, 2nd week and 1st month after treatment initiation.
resultsThe most common underlying etiology was epithelial debridement during vitrectomy and NK due to herpes simplex virus (n=6, 25.0% each), followed by chemical injury (n=4, 16.6%). While the initial epithelial defect area was 16.23±11.23 mm
conclusionTopical insulin promotes epithelial healing in PED and may improve functional corneal sensitivity, potentially reflecting enhanced corneal neurotrophic function. Its accessibility and favorable safety profile make it a promising therapeutic option.
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