ArticleClinical and translational radiation oncology2026
Memory circuit dosimetry in patients with brain metastases treated with Sparing Memory with Advanced Radiosurgery Targeting (SMART) technique.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Radiation dose reduction to major memory circuit substructures (e.g., hippocampus, amygdala, fornix, and corpus callosum) may reduce patients' neurocognitive toxicities. We evaluated memory circuit (MC) dosimetry and determined the feasibility of the "Sparing Memory with Advanced Radiosurgery Targeting" (SMART) technique in patients with brain metastases. Materials and methods: Retrospective contouring of MC substructures was performed for 101 patients that received single-fraction, linear accelerator (LINAC)-based, monoisocentric SRS plans for increasing numbers of brain metastases: 1, 2-4, 5-9 and ≥ 10. Patients with ≥10 lesions ( Results: Patients with ≥10 brain metastases received significantly higher D Conclusion: Increased number of brain metastases results in higher MC doses. Patients with ≥10 lesions received increased D
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