Evidence map›Paper›PMID 42668641›Full record

ArticleiScience2026

A transcriptomics-based computational drug repurposing pipeline identifies simvastatin and primaquine as therapeutics for endometriosis.

Tomiko T Oskotsky, Xinyu Tang, Erin Arthurs, Arpita Govil, Ferheen Abbasi, Arohee Bhoja, Daniel G Bunis, Abby Lau, Jakob Einhaus, Maïgane Diop and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Tomiko T OskotskyBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Xinyu TangBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Erin ArthursDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Arpita GovilDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Ferheen AbbasiCenter for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Arohee BhojaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Daniel G BunisBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Abby LauDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Jakob EinhausDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
Maïgane DiopDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
Juan C IrwinCenter for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
David K StevensonDepartment of Pediatrics, Stanford University, Stanford, CA, USA.
Linda C GiudiceCenter for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Stacy L McAllisterDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Project 4: Human Endometrial Programming for Successful ImplantationP50HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MELLON, SYNTHIA H · 2014 to 2022
$16.4M
UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community EngagementP01HD106414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAUDILLIERE, BRICE, GIUDICE, LINDA C · 2021 to 2025
$7.1M
Targeting Reactive Aldehyde Metabolism in Endometriosis as a treatment strategy and a Diagnostic BiomarkerR00HD093858 · NICHD · EMORY UNIVERSITY · PI MCALLISTER, STACY L · 2019 to 2021
$686k
NCATS NIH HHS UL1 TR002378NICHD NIH HHS P01 HD106414NICHD NIH HHS P50 HD055764NICHD NIH HHS R00 HD093858
6 · The paper itself

Abstract

Endometriosis has limited treatment options, prompting the search for data-driven therapeutics. We previously used a transcriptomics-based computational drug repositioning pipeline and identified several drug candidates. Fenoprofen, our top

Indexed as

drug repurposingelectronic medical recordsendometriosisgene expression reversalprimaquinereal-world dataRNA sequencingsimvastatintranscriptomicsvaginal hyperalgesia

Identifiers

PMID42668641
PMCPMC13524725

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.