ArticleNeurotrauma reports
Harmonizing the Federal Interagency Traumatic Brain Injury Research Informatics System to Study Pre-Injury Immunomodulator Exposure: A Proof-of-Concept Analysis.
Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The Federal Interagency Traumatic Brain Injury Research Informatics System (FITBIR) was designed as a centralized repository for all federally funded traumatic brain injury (TBI) datasets. FITBIR is intended to feature pre-harmonized data using specific common data elements, which can then be applied uniformly by all contributors. Yet, FITBIR is seldom used for exposure and outcomes research. This study evaluated whether FITBIR data could identify the impact of pre-injury immunomodulator exposure on post-injury outcomes. FITBIR forms were downloaded and found to contain a significant number of nonharmonized entries across studies, requiring extensive manual review and harmonization across covariates, exposures, and outcomes. Outcomes included functional, cognitive, psychiatric, and global measures. Among 52,897 participants, 204 had pre-injury immunomodulator use, and 90 had sufficient data for further analysis. All 90 exposed individuals were matched to controls, yielding a cohort of 180 participants. Least absolute shrinkage and selection operator and Firth regression were used to generate a propensity-matched cohort, with standardized mean differences of 0.62 (0.078 vs. 0.032) and 0.07 (0.078 vs. 0.073), respectively, due to the high dimensionality of the available demographic and historical covariates. Across all outcomes, except length of stay (+3.04 days in the immunomodulator group,
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Registered trials
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