Evidence map›Paper›PMID 42670048›Full record

ArticleCardiovascular therapeutics2026

Comparative Performance of Calcium-Modification Strategies for Coronary Lesions: A Network Meta-Analysis of Randomized Trials.

Fiorenzo Simonetti, Andreas T Kristensen, Tobias Lenz, Felix Voll, Moritz von Scheidt, Michael Joner, Tobias Rheude, Hendrik Sager, Erion Xhepa, Adnan Kastrati and 2 more

Abstract readNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fiorenzo SimonettiDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0001-6897-9807
Andreas T KristensenDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, rigshospitalet.dk.ORCID https://orcid.org/0000-0002-4570-236X
Tobias LenzDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0003-3041-8486
Felix VollDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0003-1034-6147
Moritz von ScheidtDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0001-7159-8271
Michael JonerDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-2971-8310
Tobias RheudeDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-3426-6080
Hendrik SagerDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-0197-6553
Erion XhepaDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-0728-2819
Adnan KastratiDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0003-4341-891X
Niels Thue OlsenDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, rigshospitalet.dk.ORCID https://orcid.org/0000-0003-1466-5225
Salvatore CasseseDepartment of Cardiovascular Diseases, TUM Klinikum Deutsches Herzzentrum, Technical University of Munich, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-8668-4313

Funding

Projekt DEAL
6 · The paper itself

Abstract

INTRODUCTION AND

objectivesCalcified coronary lesions are associated with an increased risk of percutaneous coronary intervention (PCI) failure. Despite the availability of several calcium-modification strategies and randomized trials evaluating their efficacy, comparative investigations remain scanty. The aim of the present analysis is to assess the comparative performance of calcium-modification strategies in patients undergoing PCI of calcified coronary lesions.

methodsWe conducted a systematic search for randomized trials evaluating calcium-modification strategies in patients undergoing PCI. Random-effects network meta-analyses were performed. The primary outcome was minimal stent area (MSA). Secondary outcomes included all-cause death and stent thrombosis.

resultsTwenty-two trials enrolling 4855 patients were included. Compared to calcium modification with noncompliant balloons, the use of cutting/scoring balloon (mean difference: 0.81 mm

conclusionsCompared with standard noncompliant balloons, RA and balloon-based strategies improved the mechanical performance of PCI in calcified coronary lesions. However, this did not result in better clinical outcomes.

Indexed as

Angioplasty, Balloon, CoronaryCoronary Artery DiseaseLithotripsyPercutaneous Coronary InterventionVascular CalcificationAgedCoronary ThrombosisFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsStentsTreatment Outcomeatherectomycalcified coronary lesionendovascular proceduresintravascular imaginglesion preparationmodified balloonpercutaneous coronary interventions

Identifiers

PMID42670048
PMCPMC13527234

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.