ReviewGlobal health & medicine2026
Effectiveness of human induced pluripotent stem cell-derived β-like cell/islet transplantation in animal models of diabetes: A meta-analysis of preclinical studies.
Review in Global health & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging approaches in regenerative medicine for the treatment of diabetes have attracted attention. This meta-analysis aimed to evaluate the effectiveness of human induced pluripotent stem cell (hiPSC)-derived β-like cell/ islet transplantation in animal models of diabetes. Studies using strictly controlled designs to assess hiPSC-derived β-like cell/islet transplantation were included. A reduction in blood glucose (BG) levels and improvement on the glucose tolerance test (GTT) served as indices to assess effectiveness. Twelve studies published between January 1, 2016 and December 31, 2025 were included. Pooled evidence indicates that transplantation of hiPSC-derived β-like cells/ islets is associated with significant reductions in BG levels from four weeks to two months post-transplantation, with hypoglycemic effectiveness tending to increase over time. Improvements in glucose tolerance were also consistently observed. Overall, this meta-analysis synthesizes current preclinical evidence and identifies key areas where further research is needed to clarify translational and potential clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.