Evidence map›Paper›PMID 42670443›Full record

ArticleJournal of analytical methods in chemistry2026

Harnessing the Structural Variability of Doxycycline Hyclate: Mechanistic Insights and Comparative Assessment of Four Chemically Diverse Spectrophotometric Pathways.

Mona A Abdel Rahman, Reem H Obaydo

Abstract read
In one paragraph

Article in Journal of analytical methods in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mona A Abdel RahmanAnalytical Chemistry Department, Faculty of Pharmacy, October 6 University, P. O. Box 12858, 6 October City, Giza, Egypt, o6u.edu.eg.ORCID https://orcid.org/0009-0003-0978-469X
Reem H ObaydoDepartment of Analytical and Food Chemistry, Faculty of Pharmacy, Ebla Private University, Idlib, Syria.ORCID https://orcid.org/0000-0003-1496-4612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Four distinct, chemically asynchronous spectrophotometric pathways each tapping into a different reactive node of the polyfunctional doxycycline hyclate (DOX) framework were planned to bypass the limitations of single mechanism assays. It works amazingly well. By exploiting the drug's inherent structural mutability, we developed a multipronged quantification matrix. Take the drug's reducing capacity, for instance. In Method A, this specific driving force reduces Fe (III) in the presence of potassium ferricyanide, yielding a highly conjugated Turnbull's blue complex characterized by a distinct bathochromic shift (

Indexed as

doxycycline hyclateFast Red Bion-pair extractionN-bromosuccinimideTurnbull’s blue

Identifiers

PMID42670443
PMCPMC13526241

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.