Trial reportDrug design, development and therapy2026
Peripheral Nerve Blocks Modulate the Pain-Mood Relationship in Bariatric Surgery: A Secondary Analysis of a Randomized, Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interpreting Pain-Mood Associations in a Secondary Analysis of a Bariatric Surgery Trial [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine whether adding peripheral nerve blocks (transversus abdominis plane block [TAPB] or quadratus lumborum block [QLB]) to general anesthesia (GA) was associated with improved postoperative anxiety and depressive symptoms in patients with morbid obesity undergoing laparoscopic sleeve gastrectomy (LSG). Methods: In this secondary analysis of a single-center, randomized, double-blind clinical trial (N = 225), morbidly obese patients scheduled for LSG were randomized to receive either bilateral, ultrasound-guided transversus abdominis plane block (TAPB) or quadratus lumborum block (QLB) with 0.33% ropivacaine and dexmedetomidine (1 µg/kg) before general anesthesia (GA) or general anesthesia alone. Psychological symptoms (depression and anxiety) were assessed using the Hamilton Depression and Anxiety Scale at baseline, and at 1 and 3 months postoperatively. Results: All three groups achieved significant and comparable ideal body weight loss, and overall improvements in psychological symptoms. Overall, depression symptoms decreased from 71.1% to 46.7% and anxiety from 72.4% to 48.9% at postoperative 3 months. Psychological improvement trajectories varied between groups. Relative to the GA reference group, the QLB group exhibited significantly larger declines in HAMD scores (β = -1.81, 95% CI: -2.76 to -0.87, P < 0.001) and HAMA scores (β = -1.83, 95% CI: -2.94 to -0.72, P = 0.001). QLB also performed a stronger reduction in anxiety than the TAPB group ( Conclusion: PNBs combined with general anesthesia reduced anxiety and depression 3 months after LSG. The correlation between visceral pain and anxiety suggests that improved analgesia may contribute to these psychological benefits.
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