Evidence map›Paper›PMID 42671468›Full record

ArticleArchives of microbiology2026

Immunomodulation of mixed postbiotics produced from Lactiplantibacillus plantarum KLDS1.0318 and KLDS1.0386 in vitro and in vivo.

Jiaxin Li, Le Wang, Yuqi Wang, Yimei Cui, Zhiru Qin, Yi Wang, Ziyi Zhang, Boyu Yi, Yingxue Yue

Abstract read
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In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaxin LiFood College, Northeast Agricultural University, Harbin, 150030, China.
Le WangFood College, Northeast Agricultural University, Harbin, 150030, China.
Yuqi WangHeilongjiang Jinxiang Biochemical Co., Ltd., Harbin, 150030, China.
Yimei CuiFood College, Northeast Agricultural University, Harbin, 150030, China.
Zhiru QinFood College, Northeast Agricultural University, Harbin, 150030, China.
Yi WangFood College, Northeast Agricultural University, Harbin, 150030, China.
Ziyi ZhangFood College, Northeast Agricultural University, Harbin, 150030, China.
Boyu YiFood College, Northeast Agricultural University, Harbin, 150030, China.
Yingxue YueFood College, Northeast Agricultural University, Harbin, 150030, China. 13091442027@163.com.

Funding

the Heilongjiang Province "Excellent Young Teachers' Basic Research Support Program" YQJH2024007the National Key Research and Development Program of China 2025YFF1108100
6 · The paper itself

Abstract

Postbiotics can modulate immune responses by regulating immune cell functions and promoting the secretion of immune-related cytokines. However, most studies have focused on postbiotics from single strains, while the effects of mixed postbiotics remain underexplored. This study used RAW 264.7 cells and cyclophosphamide-induced immunosuppressed mice to investigate the immunomodulatory effects of postbiotics derived from mixed Lactiplantibacillus plantarum (L. plantarum) (KLDS1.0318 + KLDS1.0386). In vitro, heat-inactivated mixed L. plantarum (HK-Mix) and its cell-free supernatant (CFS-Mix) exhibited no cytotoxic effects and significantly enhanced the phagocytic activity of RAW 264.7 cells, as well as the secretion levels of NO and cytokines (IL-6, IL-1β, and TNF-α) (P < 0.05). In vivo, HK-Mix and Post-Mix (HK-Mix + CFS-Mix) significantly alleviated cyclophosphamide-induced weight loss, increased immune organ indices, and promoted splenic lymphocyte proliferation and NK cell activity (P < 0.05). Principal component analysis revealed that HK-Mix and Post-Mix showed higher comprehensive scores in vitro and in vivo, respectively, and correlation analysis demonstrated positive correlations among indicators within each experimental setting. Therefore, mixed L. plantarum postbiotics exhibit promising immunomodulatory potential by enhancing macrophage phagocytosis, promoting the secretion of TNF-α, IL-1β, and IL-6, and improving splenic lymphocyte proliferation and NK cell activity.

Indexed as

Immunologic FactorsImmunomodulating AgentsImmunomodulationLactiplantibacillus plantarumProbioticsAnimalsCell ProliferationCyclophosphamideCytokinesInterleukin-1betaKiller Cells, NaturalMacrophagesMiceNitric OxidePhagocytosisRAW 264.7 CellsCyclophosphamideCytokinesImmunologic FactorsImmunomodulating AgentsInterleukin-1betaNitric OxideTumor Necrosis Factor-alphaImmune cellsImmunosuppressionLactiplantibacillus plantarumPostbiotics

Identifiers

PMID42671468

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.