ReviewMolecular neurobiology2026
Developmental Extracellular Matrix as a Bioactive Niche for Spinal Cord Organoid Maturation and SCI Repair.
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI) causes permanent sensorimotor deficits due to the inhibitory extracellular microenvironment that forms post-injury, hindering regeneration. The extracellular matrix (ECM) plays a critical role in neural development and repair, with the developmental spinal cord ECM being enriched in pro-regenerative molecules and containing relatively low levels of inhibitory components. In contrast, the ECM of the adult injured spinal cord is characterized by an abundance of growth-inhibitory molecules. Human pluripotent stem cell-derived spinal cord organoids have emerged as promising in vitro models for studying spinal cord development and disease; however, their application is limited by incomplete structural and functional maturation. The incorporation of developmental ECM components into organoid cultures has been shown to promote maturation, neuronal connectivity, and functional integration. This review provides a comprehensive overview of the regenerative properties of developmental spinal cord ECM and discusses its applications in organoid engineering and SCI repair, including decellularized ECM biomaterials, hydrogels, synthetic analogs, and combinatorial approaches. Collectively, developmental ECM-based strategies represent a promising platform for the development of precision regenerative therapies aimed at enhancing functional recovery after SCI.
Indexed as
Identifiers
42671729What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.